Download Adipose Tissue Biology by Christian Dani, Nathalie Billon (auth.), Michael E. Symonds PDF

By Christian Dani, Nathalie Billon (auth.), Michael E. Symonds (eds.)

This booklet is designed to supply a entire perception into present views and demanding situations in adipose tissue biology. In <i>Adipose Tissue Biology</i>, scientists and clinicians speak about adipocyte precursors, differentiation and development, brown and white adipose tissue, gender, irritation, nutritional and genetic determinants of fats mass, including evolutionary and developmental elements of adiposity.

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A parasympathetic innervation of brown adipose tissue is largely absent, with the exception of pericardial and mediastinal brown adipose tissue (Giordano et al. 2004; Schafer et al. 1998). Brown adipocytes are characterized by an abundance of small lipid droplets (multilocular) in contrast to white adipocytes which typically feature a single large lipid droplet (unilocular). They furthermore contain an unusually high amount of mitochondria which confer the eponymous brown color to the tissue. 42 M.

Some drugs show a strong influence on adipogenesis. Highly active antiretroviral therapy on human immunodeficiency virus (HIV) infection, has been associated with metabolic syndrome including insulin resistance, dyslipidemia, peripheral lipoatrophy and visceral adiposity (Leow et al. 2003). Studies in cell culture have shown that several protease inhibitors, for example nelfinavir and indinavir, decrease preadipocyte differentiation and lipogenesis, while increasing apoptosis and lipolysis (Dowell et al.

Obesity (Silver Spring) 17:2134–2141 Ortega FJ, Moreno-Navarrete JM, Pardo G et al (2010) MiRNA expression profile of human subcutaneous adipose and during adipocyte differentiation. PLoS One 5(2):e9022 Pairault J, Green H (1979) A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate dehydrogenase as differentiation marker. Proc Natl Acad Sci USA 76:5138–5142 Pei H, Yao Y, Yang Y et al (2011) Krüppel-like factor KLF9 regulates PPARg transactivation at the middle stage of adipogenesis.

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