Download Amino Acids: Chemistry, Biology and Medicine by Sir Leslie Fowden (auth.), Gert Lubec, Gerald A. Rosenthal PDF

By Sir Leslie Fowden (auth.), Gert Lubec, Gerald A. Rosenthal (eds.)

The research of amino acids is of primary curiosity to scientists from many different fields. This curiosity derives from their function because the easy materials of proteins as well as their skill to function development blocks for the construction of many periods of secondary metabolites. they could help the biosynthesis of a myriad of traditional items together with non-protein amino acids, cyanogenic glycosides, pharmacologically lively alkaloids, convinced phenols, purines and pyrimidines, nucleic acids. condensed tannins, lignins and different metabolites.
The contributions contained during this paintings originate from the 1st overseas Congress in Amino Acid study. This choice of papers will entice researchers within the fields of biochemistry, vascular and phone biology, body structure, pharmacology, endocrinology and medical drugs.

Show description

Read or Download Amino Acids: Chemistry, Biology and Medicine PDF

Similar biology books

Bacterial Toxins: Methods and Protocols

The curiosity of investigators throughout a wide spectrum of medical dis- plines has been progressively motivated by means of the sector of bacterial toxin study, a space that uses a wide number of organic, chemical, physicochemical, and medically orientated methods. Researchers learning bacterial pollution must be conversant in these kind of disciplines with a view to paintings successfully within the box.

Apoptosis

Quantity 322 of equipment in Enzymology is devoted to apoptosis. significant subject matters lined comprise measuring apoptosis and apoptosis-induced endonucleases, measuring apoptosis in decrease organisms, proteases taken with apoptosis and their inhibitors, cellphone unfastened structures for tracking steps in apoptosis pathways, mitochondria and apoptosis, bCl-2 kin proteins, and learning receptors and sign transduction occasions implicated in phone survival and telephone dying.

Molecular Biology of Chromosome Function

Chromosomes have constitution, decided via the interactions of proteins with DNA, and chromosomes have features, particularly, replication of DNA and transcription of messenger RNA. Chromosome constitution and serve as are usually not separate themes, given that chromosome association seasoned­ foundly affects the task of the genome in replication and transcrip­ tion.

Additional info for Amino Acids: Chemistry, Biology and Medicine

Example text

41: 771-779. Smith EM, Swiss OF, Neustadt BR, Oold EH, Sommer JA, Brown AD, Chiu PJS, Moran R, Sybertz EJ and Baum T (1988) J. Med. Chern. 31: 875-885. Krapcho J, Turk C, Cushman DW, Powell JR, DeForrest JM, Spitzmiller ER, Karanewsky OS, Duggan M, Rovnyak 0, Schwartz J, Natarajan S, Godfrey JD, Ryono DE, Neubeck R, Atwal KS and Petrillo Jr. EW (1988)]. Med. Chern. 31: 1148-1160. Tsuru D, Yoshimoto T, Koriyama N and Furukawa S (1988) J. Biochem. 104: 580-586. Ohta T, Hosoi A, Kimura T and Nozoe S (1987) Chemistry Lett.

Because of the ring strain of these heterocyclic bases, a considerable reactivity to ring opening reactions was expected. g. acyl chlorides [4,5] yields 1-aza-allyl cations as reactive intermediates via cleavage of the N-C bond. The hydrolysis of 3-(dimethylamino)-2,2-dimethyl-2H-azirine (la) with aqueous potassium hydrogen phosphate leads to aminoisobutyric-acid dimethylamide (AibNMe2) via cleavage of the C=N bond [6]. In this reaction, the 3-amino-2H-azirine 1 can be considered as amino-acid building block.

It is present in the seeds of 13 out of 49 species of Lathyrus [6] and in the seedlings of 14 out of 56 species. Although the toxicity of DABA is not high (LDso 69 mg/loo g body weight) the concentration in seeds of L. sylvestris is such that a single meal of the seeds can be lethal to rats [8]. DABA is metabolically derived from homo serine [13]. 3-N-oxalyl-2,3-diaminopropionic acid (ODAP) is the major toxin of L. sativus and the cause of human lathyrism [14]. It is present in all Lathyrus species linked to lathyrism [15].

Download PDF sample

Rated 4.59 of 5 – based on 22 votes