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By Ronald M. Bukowski M.D., James H. Finke Ph.D., Eric A. Klein M.D. (auth.)

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21. Kovacs G, Frisch S. Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas. Cancer Res 49:651-659, 1989. 22. Zbar B, Brauch H, Talmadge C, Linehan M. Loss of alleles of loci on theshort arm of chromosome 3 in renal cell carcinoma. Nature 327:721-724, 1987. 23. Reiter RE, Anglard P, Liu S, Gnarra JR, Linehan WM. Chromosome 17p deletions and p53 mutations in renal cell carcinoma. Cancer Res 53:30923095,1993. Thoenes W, Storkel S, Rumpelt HF, et at. Chromophobe renal cell carcinoma and its variants - report on 32 cases.

CA558. CA599. cA602. cA605. cA671, cA719. cA740. cA751. cA764. cA811. cA884 • cA982, cA985. c0180. cA26. cA41. cAllS. cA279. cAl42. cA614 • cA644 , cA720. cA775. CA785. cA926. c0400, c08ll. cB15-2. c1908. cA761. cA215. cA716. cA798. c0817. Figure 1. Localization of 219 chromosome 3p-specific cosmids to five chromosome 3p subregions. Smith et al. 43 Characterization of the Region Surrounding the Von Hippel Lindau Disease (VHLJ Gene The localization and eventual cloning of the VHL gene is an excellent demonstration of a positional cloning project that is driven by information provided by genetic linkage analysis.

Klein (Stockholm), A. Knudson (Philadelphia), Y. Nakamura (Tokyo), P. Rowley (Rochester), W. Thoenes (Mainz), and B. Zbar (Frederick) for stimulating discussions. A. ; the European Molecular Biology Organisation; and the Japanese Foundation for Promotion of Cancer Research. References 1. Kovacs G. Molecular differential pathology of renal cell tumors. Histopathology 22:1-8, 1993. 2. Ishikawa I, Kovacs G. High incidence of papillary renal cell tumours in patients on chronic haemodialysis. Histopathology 22: 135-139, 1993.

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