Download Broken Windows, Broken Business: How the Smallest Remedies by Michael Levine PDF

By Michael Levine

As soon as each few years a e-book comes in addition to an perception so penetrating, so robust - and so easily, demonstrably precise -that it immediately alterations the way in which we expect and do enterprise. one of these booklet is Broken home windows, damaged Business, a step forward in administration thought that could regulate the future of numerous businesses striving to stick prior to their festival.

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Reproduced, with permission, from ref. 8. Copyright by the American Heart Association. Myosin is best described as a molecular motor that transduces chemical energy into a mechanical force . Myosin is a ubiquitous protein found in muscle and nonmuscle cells (nonsarcomeric myosin), such as yeast and ameba, where it is used to power secretory and lysosomal vesicle transport, cytoplasmic streaming, motility, and chemotaxis. The vectorial nature of muscle contraction requires that sarcomeric myosin incorporate the catalytic properties of an ATPase protein with a structural motif that transfers chemical energy into a useful mechanical force.

A feature of the normal developing heart is the impressive increases in left ventricular wall thickness compared to the relative atrophy of the right ventricle. Experimental studies of neonatal rabbit hearts have shown higher rates of fractional protein and myosin synthesis in the left ventricle compared to the right side. 71 This relative 32 Joel Kupfer and Stanley A. 11. The cell membrane as a mechanotransducer. Five membrane-located proteins are proposed as responsive to mechanical forces. These include ion channels, porters, and second messengers .

This relationship is expressed in the well known Laplace equation. Because stress is a major determinant of cardiac metabolism, hypertrophy decreases the energy requirement per unit mass of myocardium. However, it should not be overlooked that the process of adding additional myofibrillar units is itself an energy-consuming process. Eccentric hypertrophy is seen characteristically in volume-overloaded states and is marked by progressive dilatation of the left ventricular (LV) cavity. The contractile and metabolic consequences of this type of response are more complex, but include optimization of Frank-Starling stretch-tension mechanisms and the normalization of wall stress and energy requirements through sarcomere hypertrophy.

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