Download Cholesterol: Its Functions and Metabolism in Biology and by Simon M. Jackson, Johan Ericsson, Peter A. Edwards (auth.), PDF

By Simon M. Jackson, Johan Ericsson, Peter A. Edwards (auth.), Robert Bittman (eds.)

Experts examine the biochemical and biomedical elements of ldl cholesterol, addressing its metabolism in general and illness states. They talk about a large variety of issues, together with key steps within the ldl cholesterol biosynthetic pathway, and the function of ldl cholesterol in melanoma, atherosclerosis, and illnesses of the apprehensive process. The book's accomplished insurance additionally comprises the pathological results and strength treatments for numerous sickness states, and the improvement of latest anti-atherogenic drugs.

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Natl. Acad. Sci. USA 91:8592-8596. Bonifacino, J. , 1991, Cur~ Opin. Cell BioI. 3:592-600. Bradfute, D. , and Simoni, R. , 1994, Non-sterol compounds that regulate cholesterogenesis, J. BioI. Chern. 269:6645-6650. Brown, M. , and Goldstein, J. , 1993, Mad bet for rab, Nature 366: 14-15. Byskov, A. , Andersen, C. , Nordholm, L. , Andersen, J. , 1995, Chemical structure of sterols that activate oocyte meiosis, Nature 374:559-562. Cali, J. , and Russell, D. , 1991, Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis, J.

1988, The membrane domain ofHMG-CoA reductase confers endoplasmic reticulum localization and sterol-regulated degradation onto j3-galactosidase, J. BioI. Chern. 263:6836-6841. Spear, D. : Jackson, S. , and Edwards, P. , 1994, Identification of a 6-base pair element involved in the sterol-mediated transcriptional regulation of farnesyl diphosphate synthase, J. Bioi. Chern. 269:25212-25218. , Quan, L. , Beidler, D. R, Poirier G. , Salvesen, G. , and Dixit, V. , 1995, YamalCPP32 beta, a mammalian homolog of CED-3, is a CrmAinhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase, Cell 81: 801-809.

Chern. 268:14497-14504. , Sato, R, Brown, M. , and Goldstein, J. , 1994, SREBP-l, a membrane-bound transcription factor released by a sterol-regulated proteolysis, Cell 77:53-62. , Pai, J. , Wiedenfeld, E. , Medina, J. , Slaughter, C. , Goldstein, J. , and Brown, M. , 1995, Purification of an interleukin-lj3 converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains, J. Bioi. Chern. 270:18044-18050. Wedegaertner, P.

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