Download DNA Repair and Human Disease (Medical Intelligence Unit) by Adayabalam Balajee PDF
By Adayabalam Balajee
DNA fix and Human ailment highlights the molecular complexities of some recognized human hereditary issues that come up as a result of perturbations within the constancy of various DNA fix machineries.
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Additional resources for DNA Repair and Human Disease (Medical Intelligence Unit)
WS cells are also characterized by genomic instability in the form of variegated translocation mosaicism and extensive deletions. ' WS cells display a defect in the G2-phase decatenation checkpoint which is known to inhibit progression into mitosis until chromatids are correcdy decatenated by topoisomerase II. In WS cells, failure to phosphorylate BRCAl in an ATR-dependent manner in response to decatenation checkpoint activation results in enhanced chromosomal damage and apoptosis. ^ Like BLM, WRNcscn suppress increased homologous and illegitimate recombination in the SGSl mutant.
Van Brabant AJ, Stan R, Ellis NA. DNA helicases, genomic instability, and human genetic disease. Annu Rev Genomics Hum Genet 2000; 1:409-459. 11. Karow JK, Wu L, Hickson ID. RecQ family helicases: Roles in cancer and aging. Curr Opin Genet Dev 2000; 10:32-38. 12. Ellis NA, Groden J, Ye TZ et al. The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 1995; 83:655-666. 26 DNA Repair and Human Disease 13. Yu CE, Oshima J, Fu YH et al. Positional cloning of the Werner's syndrome gene.
What is the basis of the reduced amount of TFIIH in TTD cells? In vivo, the ectopic expression of the XPD wild-type protein in XPD mutated TTD cells appeared to be sufficient to restore normal levels of the other TFIIH subunits. This increase was paralleled by the restoration of normal repair activity (Fig. 7). "^^ In vitro evidence further indicates that a mutated TFIIH subunit may affect the stability of the entire complex. ^5 j ^ ^ ^ .