Download Dopamine, Volume 21 (Handbook of Chemical Neuroanatomy) by Stephen B. Dunnett, M. Bentivoglio, A. Bjorklund, T. Hokfelt PDF

By Stephen B. Dunnett, M. Bentivoglio, A. Bjorklund, T. Hokfelt

Dopamine is an incredible neurotransmitter of the mind serious about the keep an eye on of move, emotion, and cognition; disturbance in dopamine functionality is linked to problems like Parkinson's affliction, schizophrenia and a focus deficit hyperactivity disease. This quantity of the instruction manual of Chemical Neuroanatomy presents a chain of intensive serious reports of our current knowing of an important facets of dopamine's enterprise and disturbed functionality within the animal and human mind.

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Bentivoglio and M. Morelli Fig. 6. The plate illustrates a section through the rostral level of the ventral midbrain tegmentum as presented in two different atlases of the mouse brain, to show nuclear subdivisions delineated by different authors, and for a comparison between the mouse and the rat (shown in Figs. 4 and 5). Abbreviations in A, B: CLI, central linear nucleus of the raphe; cpd, cerebral peduncle; DGmo, dentate gyrus, molecular layer; dtd, dorsal tegmental decussation; EW, Edinger-Westphal nucleus; IF, interfascicular nucleus; ipf, interpeduncular fossa; IPNc, interpeduncular nucleus, caudal part; IPNi, interpeduncular nucleus, intermediate part; IPNl, interpeduncular nucleus, lateral part; IPNr, interpeduncular nucleus, rostral part; LM, lateral mammillary nucleus; ml, medial lemniscus; mlf, medial longitudinal fasciculus; MM, medial mammillary nucleus; MT, medial terminal nucleus of the accessory optic tract; mtg, mammillotegmental tract; PN, paranigral nucleus; po, polymorphic layer; POL, posterior limitans nucleus of the thalamus; PP, peripeduncular nucleus; RL, rostral linear nucleus of the raphe; RN, red nucleus; rust, rubrospinal tract; scp, superior cerebellar peduncle; sg, granule cell layer; SNc, substantia nigra, compact part; SNl, substantia nigra, lateral part; SNr, substantia nigra, reticular part; VTA, ventral tegmental area; vtd, ventral tegmental decussation.

The crosstalk between glia and neurons, including a key role of glia in neurotransmission, is now receiving increasing attention (see, for example, Haydon, 2000). In relation to the glia which co-inhabit the mesencephalic tegmentum in the normal brain, it is interesting to note that studies on astrocytes and microglia have pointed out peculiarities of the latter type of glial cells. , 2000). , 2000) reported instead that microglia has a very high density in the SN. , 1990). , 1999; Streit, 2002).

According to Halliday and To¨rk (1986), the region of the ventromedial mesencephalic tegmentum contains approximately 27,000 cells in the rat (and approximately 47,000 cells in the monkey and 690,000 cells in the human). Swanson (1982) calculated that about 80% of these cells are TH-immunopositive, and therefore dopaminergic, in the rat VTA (see 17 Ch. I M. Bentivoglio and M. Morelli Fig. 10. The plate illustrates details of midbrain dopaminergic neurons labeled by tyrosine hydroxylase immunoreactivity.

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