Download Evolution of Evidence for Selected Nutrient and Disease by Institute of Medicine (U. S.), National Academy of Sciences PDF

By Institute of Medicine (U. S.), National Academy of Sciences (U. S.) Committee on the Implications of Dioxin in the Food Supply

Document from the Committee on exam of the Evolving technological know-how for supplements, nutrients and meals Board, and Institute of drugs. Addresses subject matters reminiscent of, Can the medical approach be speeded up by way of deciding upon styles of evolving facts to yield proven findings for public coverage? and will unexpected components be pointed out to supply warning to shoppers? tender.

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Record from the Committee on exam of the Evolving technology for supplements, meals and meals Board, and Institute of medication. Addresses themes similar to, Can the clinical process be sped up by means of opting for styles of evolving proof to yield proven findings for public coverage?

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The DRI report stated, “These trials indicate a lack of evidence of overall benefit on total cancer or cardiovascular disease and possible harm in certain subgroups such as current smokers or asbestos-exposed subjects” (p. 371). Although this indicates a failure to substantiate the hypothesis that bcarotene might prevent lung cancer, several caveats were noted in the DRI report. Plasma concentrations achieved in the clinical trials where adverse effects on lung cancer were noted are outside the range achieved through dietary intake (p.

1996). , 1993). 30. , 1993). While an understanding of gastric cancer etiology has evolved considerably over the past several years, including identification of a possible mechanistic basis for vitamin C preventive effects, large-scale randomized trials were unable to demonstrate this benefit. , short duration of intervention, only one dose tested, or results may not be generalizable to other populations with different risk factor profiles). Vitamin E and Cancer Diet and Health Report At the time of the publication of the D&H report, animal studies and observational cohort studies of vitamin E and cancer were available.

Most of the studies reviewed demonstrated that the higher calcium intakes reduced the amount of bone loss, although some found no effect. The studies were limited in that they were relatively short in duration, the methods of measurement of bone mass and site of measurement were highly variable, and the populations in the different studies varied in age and osteoporosis status. None of the studies was designed to demonstrate an association between lifetime intake of calcium and risk of developing osteoporosis.

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